Alterations in Hippocampal Functional Connectivity in patients with Mesial Temporal Sclerosis
نویسندگان
چکیده مقاله:
Introduction: Medial temporal sclerosis (MTS) is a form of mesial temporal lobe epilepsy (mTLE). It is typically characterized by structural alterations in hippocampus (HC) and related mesial temporal lobe (MTL) network. Resting state functional connectivity (RSFC) is considered an ideal technique in quantifying the dysfunction and maladaptation in MTL network. It is well- demonstrated that the seizure effects go beyond epileptogenic zones and alterations in connectivity are fairly widespread across cortical and subcortical regions. This study aims to assess the alterations in RSFC in hippocampus in patients with MTS. Materials and Methods: Resting state Functional magnetic resonance imaging was performed during interictal activity on 18 patients with MTS (7 patients with right and 11 patients with left MTS). Preprocessing included removing the first 10 time points, slice timing, head motion correction, normalization and removing the linear fMRI signal trend. Processing and statistical analysis were conducted using DPARSF and MATLAB, respectively. For all patients, the RSFC for both right and left hippocampi to 116 regions of interest (ROIs) were calculated and statistically analyzed. Connectivity of left and right hippocampi were compared between left and right MTS cohorts using paired t-student test. Results: Statistically significant differences between left and right hippocampi were observed in 1 and 15 ROIs for right and left MTS cohorts, respectively. Left paraHippocampus was the only ROI with significant difference in RSFC with right and left hippocampi in right MTS patients. Left Amygdala, Right Rolandic_Ope, Cingulum_posterior, paraHippocampus, Occipital_Inf, Fusiform, Parietal_Inf, Supra Marginal, Angular, Heschl, Temporal_Sup, Temporal_Mid, Temporal_Pole_Mid, Temporal_Inf gyri, and Cerebelum_4_5 showed significant difference between their connectivity with respect to left and right hippocampi in patients with left MTS. Conclusion: Left MTS may be associated with more extensive network impairment compared to right MTS. This result is in agreement with previous studies (Pereira et al and Doucet et al). Our findings also show that the behaviour of left paraHippocampus in the alteration in RSFC can be used as an indication for Right MTS.
منابع مشابه
Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.
BACKGROUND AND PURPOSE Unilateral mesial temporal lobe epilepsy and hippocampal sclerosis have structural and functional abnormalities in the mesial temporal regions. To gain insight into the pathophysiology of the epileptic network in mesial temporal lobe epilepsy with hippocampal sclerosis, we aimed to clarify the relationships between hippocampal atrophy and the altered connection between th...
متن کامل[Mesial temporal sclerosis syndrome in adult patients].
Magnetic resonance imaging (MRI) has become an essential tool in the work-up of epilepsy. Since its appearance it has been possible to identify pathologies, such as hippocampal sclerosis (HS), that had previously only been detected by histopathological assays. The aim of this study was to analyze the clinical manifestations, EEG and the outcome of patients with HS as shown by MRI. We revised th...
متن کاملProspective memory and mesial temporal epilepsy associated with hippocampal sclerosis.
Episodic memory impairment is commonly observed in patients with epilepsy associated with mesial temporal sclerosis (MTS). Prospective memory (PM) is a set cognitive abilities that allow future performance of a present intention, in response to time- or event-based evocation cues, that trigger the intended action at the appropriate time. PM has not been evaluated in mesial temporal sclerosis. W...
متن کاملInterleukin-1β Secretion in Hippocampal Sclerosis Patients with Mesial Temporal Lobe Epilepsy
Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common medically intractable epilepsy syndrome. Although pathogenesis of HS still remains highly controversial, genetics may play a role as a predisposing factor. Previous evidence in a Japanese population revealed that the homozygotes for allele T at position -511 of the interleukin (IL)-1β gene promoter region (IL-1β-511 ...
متن کاملAmygdala Enlargement in Patients with Mesial Temporal Lobe Epilepsy without Hippocampal Sclerosis
PURPOSE Patients with mesial temporal lobe epilepsy (MTLE) without MRI abnormalities (MTLE-NL) represent a challenge for definition of underlying pathology and for presurgical evaluation. In a recent study we observed significant amygdala enlargement (AE) in 14% of MTLE patients with MRI signs of hippocampal sclerosis. Areas of gray matter volume (GMV) increase could represent structural abnorm...
متن کاملMagnetic resonance spectroscopy of the thalamus in patients with mesial temporal lobe epilepsy and hippocampal sclerosis.
PURPOSE to investigate potential neuronal dysfunction within the thalamus in patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE/HS). METHODS we examined twenty epileptic patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis (17 females, 3 males) and twenty sex- and age-matched healthy controls. H MR spectroscopic imaging (SI) was ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 15 شماره Special Issue-12th. Iranian Congress of Medical Physics
صفحات 312- 312
تاریخ انتشار 2018-12-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023